Giles's other TV credits are Doctors, Dangerfield, Coronation Street and Midnight Man. Her stage credits include A Taste of Honey (as Helen), Dead Funny (Lisa), and Season's Greetings (Belinda).
In December 2007 it was announced that, in 2008, Giles had joined the cast of the Channel 4 teen soap Hollyoaks as Valerie Holden, a role that was taken over from actress Jacqueline Leonard. She has since left Hollyoaks on maternity leave, written out as moving to Spain. However she returned in July 2010, and left again in August 2010. In December 2010, Giles appeared on Celebrity Mastermind where her specialist subject focused on the works of Alfred Hitchcock. Giles returned to Emmerdale in the Autumn of 2012.